PKF South Africa https://www.cerbalancetafrica.ke/ High Sensitivity Cardiac Troponin I (hs-cTnI)

Acute Myocardial Infarction (AMI) is the major cause of death and disability worldwide with an increasing incidence. The risk of death is highest within the first few hours of AMI onset. Rapid identification of AMI is critical for the initiation of medical treatment and management. 

Acute Myocardial Infarction (AMI) is the major cause of death and disability worldwide with an increasing incidence. The risk of death is highest within the first few hours of AMI onset. Rapid identification of AMI is critical for the initiation of medical treatment and management. Fortunately, most patients presenting at emergency clinics with chest pain do not have AMI.

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8/18/2022 12:00:00 PM https://www.cerbalancetafrica.ke/news/pathologists-corner/high-sensitivity-cardiac-troponin-i-hs-ctni/
Lipoprotein

Lipoprotein (a) also referred to as Lp (a) is structurally similar to LDL- C with the exception of the presence of apolipoprotein (a) or apo (a) moiety attached to its apo B component1. Apo(a) shares homology with the fibrin binding domain of plasminogen leading to impaired conversion to its active form plasmin. 

Lipoprotein (a) also referred to as Lp (a) is structurally similar to LDL- C with the exception of the presence of apolipoprotein (a) or apo (a) moiety attached to its apo B component1. Apo(a) shares homology with the fibrin binding domain of plasminogen leading to impaired conversion to its active form plasmin. In addition, Lp (a) is associated with infiammation through pathological interaction with monocytes and endothelial cells2.

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8/18/2022 12:00:00 PM https://www.cerbalancetafrica.ke/news/pathologists-corner/lipoprotein/
D – dimer

D dimer has been in use for almost three decades, as a screening tool for Venous thromboembolism (VTE)¹. It is one of many Fibrin degradation products (FDP) produced after a clot is degraded by the process of fibrinolysis. FDPs come in a variety of molecular weights.

D dimer has been in use for almost three decades, as a screening tool for Venous thromboembolism (VTE)¹. It is one of many Fibrin degradation products (FDP) produced after a clot is degraded by the process of fibrinolysis. FDPs come in a variety of molecular weights. However, unlike other FDPs that are formed following degradation of fibrinogen and fibrin, D – dimer is produced exclusively from cross-linked fibrin. D dimer is therefore indicative of clot degradation and not non-specific fibrinolysis2.

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1/1/0001 12:00:00 AM https://www.cerbalancetafrica.ke/news/pathologists-corner/d-dimer/